Three series of isomeric 2-pyridyl 4-aryl thiazoles have been synthesized by reacting 2/3/4-pyridine thioamides derived from the corresponding nitriles with various 4-substituted phenacyl bromides using Hantzsch thiazole synthesis. Amongst the three isomeric series, 2-pyridyl and 4-pyridyl isomers are found to exhibit better photophysical properties than 3-pyridyl series. 4-Pyridyl isomer with methoxy substituent on phenyl ring is found to exhibit high luminescence quantum yield. The relationship between the structure and the photophysical properties have been studied using DFT calculations.

中文翻译：

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新型噻唑取代吡啶衍生物的合成，表征和光物理性质

使用Hantzsch噻唑合成法，通过使衍生自相应腈的2/3 / 4-吡啶硫代酰胺与各种4-取代的苯甲酰溴反应，合成了三组异构的2-吡啶基4-芳基噻唑。在三个异构体系列中，发现2-吡啶基和4-吡啶基异构体比3-吡啶基系列具有更好的光物理性质。发现在苯环上具有甲氧基取代基的4-吡啶基异构体表现出高的发光量子产率。结构和光物理性质之间的关系已使用DFT计算进行了研究。