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Synthesis and characterization of novel chelation-free Zn(II)-azole complexes: Evaluation of antibacterial, antioxidant and DNA binding activity
Indian Journal of Chemistry, Section A Pub Date : 2020-06-17
Sondavid K Nandanwar, Shweta B Borkar, Bryan Nathanael Wijaya, Enkhnaran Bayarra, Lei Lottice Anne Piad, QiuLi Jin, Celine Sheila Tiara, Hak Jun Kim, Naresh H. Tarte

Here, we synthesized novel chelation-free Zn(II)-complexes (1-3) [ZnCl2L2] of monodentate ligands with L = 2-isopropylimidazole (L1), 2-methylbenzimidazole (L2), and 2-methylbenzoxazole (L3) and evaluated their antibacterial, antioxidant and DNA binding activities. The chelation-free properties of these coordination complexes were confirmed by UV-visible spectroscopy, 1H NMR spectroscopy, single X-ray crystallography and elemental analysis. Complexes 1-3 exhibited substantial antibacterial activity against all antibiotic susceptible bacteria within a concentration range of 100-200 µg/ml while free ligands L1 and L2 exhibited weak antibacterial activity considerably concentration above 200 µg/ml. Also, both complexes 2 and 3 were twice more active against methicillin-resistant Staphylococcus aureus (MRSA) than complex 1. Furthermore, we found that complexes 1-3 showed DNA binding activity with E. coli plasmid DNA and calf thymus DNA, which may be a plausible mechanism for their antibacterial activity. We also investigated the antioxidant activity of complexes 1-3 and found that complex 2 exhibited potential antioxidant activity compared to complexes 1 and 3. All these results suggest that the chelation-free Zn(II)-complexes can be the future candidates for more advance biological studies.

中文翻译:

新型无螯合Zn(II)-唑配合物的合成和表征:抗菌,抗氧化剂和DNA结合活性的评估

在这里,我们合成了新颖的螯合不含Zn(II)-complexes(1 - 3)的ZnCl 2大号2单齿配体与L = 2异丙基咪唑(的] L1),2-甲基苯并咪唑(L2),和2-甲基苯并恶唑(L3),并评估它们的抗菌,抗氧化剂和DNA结合活性。这些配位配合物的无螯合性质通过紫外可见光谱,1 H NMR光谱,单X射线晶体学和元素分析得到证实。配合1 - 3在100-200 µg / ml的浓度范围内,对所有抗生素敏感细菌均显示出显着的抗菌活性,而游离配体L1L2在200 µg / ml以上的浓度下均显示出较弱的抗菌活性。此外,两种复合23对耐甲氧西林的两倍更活性的金黄色葡萄球菌MRSA 不是复杂1。此外,我们发现,复合物1 - 3显示DNA结合活性与大肠杆菌质粒DNA和小牛胸腺DNA,这可能是其抗菌活性的合理机制。我们还调查复合物的抗氧化活性1 - 3后发现,复杂的2表现出潜在的抗氧化活性比复合物13。所有这些结果表明,无螯合的Zn(II)络合物可以成为更高级生物学研究的未来候选者。
更新日期:2020-07-28
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