A reaction between 1-(furan-2-yl)-3,4-dihydroisoquinoline and thioglycolic acid using N,N-Dicyclohexylcarbodiimide at 0−5 °C has given 10b-(furan-2-yl)-5,6-dihydro-2H-thiazolo[2,3-a]isoquinolin-3(10bH)-one [FUIQTGA]. The interaction between FUIQTGA and DNA has been studied using UV-visible spectroscopy, fluorescence and circular dichroism techniques. Static quenching mechanism is observed from fluorescence measurements of interaction between FUIQTGA and DNA. Circular dichroism reveals the minor groove binding mode between FUIQTGA and DNA.

中文翻译：

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噻唑洛[2，3-a]异喹啉类似物与DNA的合成及相互作用

1-（呋喃-2-基）-3,4-二氢异喹啉与巯基乙酸在0-5°C下使用N，N-二环己基碳二亚胺反应得到10b-（呋喃-2-基）-5,6-二氢-2H-噻唑并[2，3-a]异喹啉-3（10bH）-1 [FUIQTGA]。已经使用紫外-可见光谱，荧光和圆二色性技术研究了FUIQTGA与DNA之间的相互作用。从FUIQTGA和DNA之间相互作用的荧光测量中观察到静态淬灭机理。圆二色性揭示了FUIQTGA与DNA之间的小沟结合模式。