The crystals size and distribution play an important role in drug properties which has a major impact on the performance e.g., stability, solubility and bioavailability. The crystal size distribution (CSD) depends on the hydrodynamics and local degree of supersaturation in the crystallizer. In this study, we have investigated the effects of various operating conditions (antisolvent ratio, power, agitator design) using different mixing techniques such as impellers and ultrasound on CSD and average crystal size (ACS). It is found that mixing plays a dominant role in CSD and ACS. The hydrofoil (axial flow impeller) provides a wide range of ACS (406 to 240 μm) at lower power as compared to Rushton turbine (radial flow impeller) (395 to 375 μm). The mixed flow impeller produces the intermediate crystal size (365 to 345 μm). The increase in the antisolvent ratio results in a decrease in ACS. The same results observed for the power input.

中文翻译：

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反溶剂结晶的实验研究：反溶剂比例和混合方式的影响

晶体的大小和分布在药物特性中起着重要作用，而药物特性对性能（例如稳定性，溶解性和生物利用度）具有重要影响。晶体尺寸分布（CSD）取决于结晶器中的流体动力学和局部过饱和度。在这项研究中，我们研究了使用不同的混合技术（例如叶轮和超声）对CSD和平均晶体尺寸（ACS）的各种操作条件（抗溶剂比，功率，搅拌器设计）的影响。发现混合在CSD和ACS中起主要作用。与Rushton涡轮机（径向流叶轮）（395至375μm）相比，水翼（轴流叶轮）以较低的功率提供了广泛的ACS（406至240μm）。混流叶轮产生中等晶体尺寸（365至345μm）。抗溶剂比例的增加导致ACS的降低。对于电源输入，观察到的结果相同。