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High dilutions of two drugs induce changes in crystal water structure of lactose as revealed by thermogravimetry and differential scanning calorimetry
Indian Journal of Biochemistry and Biophysics ( IF 1.5 ) Pub Date : 2020-07-27
Priya Mondal, Nirmal Chandra Sukul, Anubha Dey, Ashis Bhattacharjee, Md Amir Sohel, Asmita Sengupta, Anirban Sukul

Ultra-high dilutions (UHD) of drugs used in homeopathy are preserved in sugars. How do solid sugars assimilate characteristics of UHDs? This study attempts to answer this question. The three UHDs of Acid fluoric, Acid nitric, and ethanol were mixed with lactose at 1 µL/g and analyzed by thermogravimetry (TG) and differential scanning calorimetry (DSC) to see any change in their crystal water. TG results show a mass loss of 4.9% at 146.8ºC for Acid fluoric 30 cH, of 7.1% at 146.6ºC for Acid nitric 30 cH, and 5.1% at 146.5ºC for ethanol. DSC results show that the change in enthalpy for Acid fluoric 30 cH is 157.3 J/g at 153.8ºC, that for Acid nit 30 cH is 122.8 J/g at 148.3ºC, and that for ethanol is 154.9 J/g at 156.3ºC. Bound water in lactose crystals and corresponding enthalpies vary markedly in the three drugs tested. This indicates that the number of hydrogen bonds and their bond strength vary inbound water of medicated lactose crystals.

中文翻译:

热重法和差示扫描量热法表明,两种药物的高稀释度会引起乳糖结晶水结构的变化

顺势疗法中使用的药物的超高稀释度(UHD)保存在糖中。固体糖如何吸收UHD的特性?这项研究试图回答这个问题。将酸性氟,酸性硝酸和乙醇的三种UHD以1 µL / g的浓度与乳糖混合,并通过热重法(TG)和差示扫描量热法(DSC)进行分析,以查看其结晶水中的任何变化。TG结果表明,酸性氟30 cH在146.8ºC时质量损失为4.9%,酸性硝酸30 cH在146.6ºC时质量损失为7.1%,乙醇在146.5ºC时质量损失为5.1%。DSC结果表明,酸性氟30 cH在153.8ºC时的焓变化为157.3 J / g,酸性尼特30 cH在148.3ºC时的焓变化为122.8 J / g,乙醇在156.3ºC时的焓变化为154.9 J / g。乳糖晶体中的结合水和相应的焓在所测试的三种药物中明显不同。
更新日期:2020-07-28
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