The burden of the management of problematic skin wounds characterized by a compromised skin barrier is growing rapidly. There is an urgent requirement for efficient mechanism-based treatments and more efficacious drug delivery systems. The present study was aimed to examine the wound healing potential of Juglans regia L. root (JR) in rats by incision and excision wound methods via the anti-inflammatory, antioxidant and antimicrobial activities. We have used tensile strength and biochemical parameters for studying the wound healing properties of JR by incision wound methodology. The anti-inflammatory effect was assessed by the measurement of paw edema in carrageenan-induced inflammation in rats. The wound contraction area, antioxidant status, and antimicrobial studies were exhausted excision wound methodology. There was a significant decrease in percent inhibition of paw edema (0.63 ± 0.03 to 0.33 ± 0.02 after 24 h) with an increase in JR concentration. Tensile strength and hydroxyproline level of different concentrations (1, 2.5, 5, and 10% w/w) of JR ointment treated groups were found significantly (P <0.001) comparable to the reference group. Moreover, JR showed significant antimicrobial and antioxidant properties, by its ability to increase antioxidant and antimicrobial levels. In conclusion, the overall results obtained in this study clarify that JR inhibits paw edema and accelerates cutaneous wound healing.

中文翻译：

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通过抗氧化，抗微生物和抗炎活性评估胡桃根的伤口愈合能力

以皮肤屏障受损为特征的有问题的皮肤伤口的管理负担正在迅速增加。迫切需要基于机制的有效治疗和更有效的药物输送系统。本研究旨在通过切口和切除伤口方法通过抗炎，抗氧化和抗菌活性来研究胡桃根（JR）在大鼠中的伤口愈合潜力。我们已使用抗张强度和生化参数通过切口伤口方法研究了JR的伤口愈合特性。通过测量角叉菜胶诱发的大鼠炎症中的爪水肿来评估抗炎作用。伤口收缩面积，抗氧化状态和抗菌研究已用尽了切除伤口的方法。随着JR浓度的增加，爪水肿的抑制百分比显着降低（24小时后为0.63±0.03至0.33±0.02）。发现JR软膏治疗组不同浓度（1、2.5、5和10％w / w）的拉伸强度和羟脯氨酸水平与参考组相当（P <0.001）。此外，JR通过增加抗氧化剂和抗菌剂的水平而显示出显着的抗菌和抗氧化剂特性。总之，在这项研究中获得的总体结果阐明，JR抑制爪水肿并加速皮肤伤口愈合。和软膏治疗组的10％w / w）被发现与参考组相当（P <0.001）。此外，JR通过增加抗氧化剂和抗菌剂的水平而显示出显着的抗菌和抗氧化剂特性。总之，在这项研究中获得的总体结果阐明，JR抑制爪水肿并加速皮肤伤口愈合。和软膏治疗组的10％w / w）被发现与参考组相当（P <0.001）。此外，JR通过增加抗氧化剂和抗菌剂的水平而显示出显着的抗菌和抗氧化剂特性。总之，本研究获得的总体结果表明，JR抑制爪水肿并加速皮肤伤口愈合。