In this study, we tried to understand better the association of oxidative stress and inflammation with type-2 diabetes and diabetic nephropathy to provide a basis for investigating improved diagnostic possibilities, treatment and prevention of the disease. Blood samples were collected from 498 West Indian individuals aged 42–72 years. Differences in the level of oxidative stress markers (MDA, GSH, SOD and CAT) and inflammation (TNF-α and IL1-α) was determined in patients (type 2 diabetic and diabetic nephropathy) and control participants. Patients with nephropathy showed significantly decreased SOD, GSH levels, but significantly increased MDA and CAT activity compared to DM patients as well as controls. Significant higher level of expression of TNF-α and IL1-α (P< 0.05) was observed in DM and DN patients as compared to controls. The results suggest that oxidative stress and inflammation are triggered in patients of type 2 diabetes and diabetic nephropathy possibly due to hyperglycemia.

中文翻译：

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氧化应激生物标志物和炎症在糖尿病和糖尿病肾病发病机理中的评估

在这项研究中，我们试图更好地了解氧化应激和炎症与2型糖尿病和糖尿病性肾病的关系，从而为研究改善的诊断可能性，治疗和预防疾病提供基础。血液样本是从498位年龄在42-72岁的西印度人身上采集的。确定了患者（2型糖尿病和糖尿病肾病）和对照组参与者的氧化应激指标（MDA，GSH，SOD和CAT）和炎症（TNF-α和IL1-α）水平的差异。与DM患者和对照组相比，肾病患者的SOD，GSH水平明显降低，但MDA和CAT活性显着提高。TNF-α和IL1-α（P与对照组相比，在DM和DN患者中观察到<0.05）。结果表明，可能由于高血糖导致2型糖尿病和糖尿病肾病患者触发了氧化应激和炎症。