TOPAS-nBio was used to simulate, collision-to-collision, the complete trajectories of electrons in water generated during the explicit simulation of 64 Cu decay. S-values and direct damage to the DNA were calculated representing the cell (C) and the cell nucleus (N) with concentric spheres of 5 μ m and 4 μ m in radius, respectively. The considered ‘target’←‘source’ configurations, including the cell surface (Cs) and cytoplasm (Cy), were: C←C, C←Cs, N←N, N←Cy and N←Cs. Ionization cluster size distributions were also calculated in a cylinder immersed in water corresponding to a DNA segment of 10 base-pairs in length (diameter 2.3 nm, length 3.4 nm), modeling a radioactive point source moving from the central axis to the edge of the cylinder. For that, the first moment (M 1 ) and cumulative probability of having a cluster size of 2 or more ionizations in the cylindrical volume (F 2 ) were obtained. Finally, the direct damage to the DNA was es...

中文翻译：

---

放射性核素Copper-64的蒙特卡洛轨道结构：S值表征，纳米剂量测定和对DNA的直接损伤定量

TOPAS-nBio被用于碰撞碰撞模拟在显式模拟64 Cu衰变过程中产生的水中电子的完整轨迹。计算出分别代表同心球半径为5μm和4μm的细胞（C）和细胞核（N）的S值和对DNA的直接损伤。包括细胞表面（Cs）和细胞质（Cy）在内的“目标”←“源”构型为：C←C，C←Cs，N←N，N←Cy和N←Cs。还计算了一个圆柱体的电离簇大小分布，该圆柱体浸入水中，该圆柱体对应于长度为10个碱基对的DNA片段（直径2.3 nm，长度3.4 nm），模拟了一个放射性点源从中心轴移动到容器边缘的过程。圆筒。为了那个原因，获得第一矩（M 1）和在圆柱体体积（F 2）中具有2个或更多个电离的簇尺寸的累积概率。最后，对DNA的直接破坏是……