Osteoporotic bone defects are a major challenge in clinics for bone regeneration. With the condition of osteoporosis, excessive bone absorption and impaired osteogenesis result in unexpectedly long healing procedures for defects. In order to simultaneously enhance bone formation and reduce bone resorption, a polydopamine-coated porous titanium scaffold was designed, to be integrated with anti-catabolic drug zoledronic acid nanoparticles (ZOL loaded gelatin NPs), which was able to achieve a local sustained release of ZOL as expected. The in vitro study demonstrated that extracts of the composite scaffolds would stimulate osteoblast differentiation; they also inhibited osteoclastogenesis at a ZOL loading concentration of 50 μmol l −1 . In the subsequent in vivo study, the composite scaffolds were implanted into ovariectomy-induced osteoporotic rabbits suffering from femoral condyles defects. The results indicated that the composite scaffolds without ZOL load...

中文翻译：

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使用新型唑来膦酸负载明胶纳米颗粒集成多孔钛支架调节骨形成和吸收：一项体外和体内研究。

骨质疏松性骨缺损是临床骨再生的主要挑战。在骨质疏松症的情况下，过度的骨吸收和成骨受损导致缺损的愈合过程出乎意料地长。为了同时增强骨形成和减少骨吸收，设计了一种聚多巴胺涂层的多孔钛支架，与抗分解代谢药物唑来膦酸纳米颗粒（ZOL 负载明胶 NPs）相结合，能够实现局部缓释ZOL 正如预期的那样。体外研究表明复合支架的提取物会刺激成骨细胞分化；它们还在 50 μmol l -1 的 ZOL 加载浓度下抑制破骨细胞生成。在随后的体内研究中，将复合支架植入卵巢切除引起的股骨髁缺损骨质疏松兔。结果表明，无ZOL负载的复合支架...