The endoplasmic reticulum (ER) is a dynamic intracellular network responsible for folding and maturation of organellar and secreted proteins. Selective autophagy of ER (ER‐phagy) is emerging as an essential process that maintains proteostasis in the ER and is regulated by growth conditions. In this issue, Cinque et al (2020) show that fibroblast growth factor 18 (FGF18) specifically activates ER‐phagy through a TFEB/TFE‐dependent transcriptional regulation of the ER‐phagy receptor Fam134b, a process essential for bone ossification and skeletal development.

中文翻译：

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选择性自噬熊骨。

内质网 (ER) 是一个动态的细胞内网络，负责细胞器和分泌蛋白的折叠和成熟。ER 的选择性自噬（ER-phagy）正在成为维持 ER 中蛋白质稳态并受生长条件调节的重要过程。在本期杂志中，Cinque等人(2020) 表明，成纤维细胞生长因子 18 (FGF18) 通过 TFEB/TFE 依赖性内质网吞噬受体 Fam134b 转录调节特异性激活内质网吞噬，这是骨化和骨骼发育所必需的过程.