Dengue is a major health threat related to arbovirus and is endemic in more than 100 countries with an annual estimated above 390 million incidences of infection all around the world. During the period 1996-2015, a considerable increase in the number of dengue cases (more than 500%) was reported in India. Information about dengue disease burden, its prevalence, incidence and geographic distribution is critical in planning appropriate control measures against dengue fever. Till date, no specific treatment for dengue fever is available in any system of medicine, which can be accepted globally. Therefore, safe, cost-effective, and efficacious agents possessing anti-viral potential against dengue virus are needed to be searched in order to fight the dengue infection globally. The aim of the present review is to systematically revise the published research work available concerning the development and evaluation of some heterocyclic scaffolds in the management of dengue.

登革热是与虫媒病毒有关的主要健康威胁，在全球100多个国家中普遍存在，估计每年有3.9亿以上的感染发生率。据报告，在1996年至2015年期间，印度的登革热病例数量大幅增加（超过500％）。有关登革热疾病负担，其流行程度，发病率和地理分布的信息对于规划针对登革热的适当控制措施至关重要。迄今为止，在任何医学体系中都没有针对登革热的具体治疗方法，这种方法已为全球所接受。因此，需要寻找具有抗登革热病毒抗病毒潜力的安全，具有成本效益的有效药剂，以在全球范围内对抗登革热感染。