Background: Lymphedema is characterized by an accumulation of interstitial fluids due to inefficient lymphatic drainage. Primary lymphedema is a rare condition, including congenital and idiopathic forms. Secondary lymphedema is a common complication of lymph node ablation in cancer treatment. Previous studies on secondary lymphedema lymphatic vessels have shown that after an initial phase of ectasia, worsening of the disease is associated with wall thickening accompanied by a progressive loss of the endothelial marker podoplanin.

中文翻译：

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对原发性和继发性淋巴水肿病理生理学的新见解：人类淋巴收集血管的组织病理学研究。

背景：淋巴水肿的特点是由于淋巴引流效率低下导致间质液积聚。原发性淋巴水肿是一种罕见的疾病，包括先天性和特发性形式。继发性淋巴水肿是癌症治疗中淋巴结消融的常见并发症。先前对继发性淋巴水肿淋巴管的研究表明，在扩张的初始阶段之后，疾病的恶化与壁增厚相关，并伴有内皮标志物podoplanin 的进行性丢失。