BackgroundPain has been qualified under four categories: nociception, perception of pain, suffering, and pain behaviors. Most of the literature on migraine has devoted attention to the first two. The aim of the present cohort study was to investigate patients with migraine enrolled at a tertiary care unit to study suffering and mental pain and identify potential risk factors for migraine.MethodsAn observational cross-sectional study was carried out on patients with chronic migraine (CM) and episodic migraine (EM), and healthy subjects (HS). The three groups were matched for age and sex. A comprehensive assessment of migraine disability, pain, psychiatric disorders, psychosomatic syndromes, depressive and anxious symptoms, euthymia, psychosocial variables, mental pain, and pain-proneness (PP) was performed.ResultsThree hundred subjects were enrolled (100 CM, 100 EM, and 100 HS). Based on the multiple regression analyses, those presenting PP (social impairment: odds ratio [OR] = 3.59, 95% confidence interval [CI] = 1.14-11.29; depressive symptoms: OR = 3.82, 95% CI = 1.74-8.41) were more likely to be CM than HS. Those with higher levels of PP (social impairment: OR = 4.04, 95% CI = 1.60-10.22; depressive symptoms: OR = 2.02, 95% CI = 1.26-3.24) were more likely to be EM than HS. Those presenting higher levels of mental pain were more likely to be CM than EM (OR = 1.45, 95% CI = 1.02-2.07).ConclusionMigraine is an unpleasant sensory and emotional experience associated with psychosocial manifestations that might contribute to the level of suffering of the individuals. Mental pain resulted to be the variable that most differentiated patients with CM from EM.

中文翻译：

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偏头痛患者的心理疼痛和疼痛倾向：PAINMIG 队列研究的结果

背景疼痛分为四类：伤害感受、疼痛感知、痛苦和疼痛行为。大多数关于偏头痛的文献都将注意力集中在前两者上。本队列研究的目的是调查在三级医疗机构登记的偏头痛患者，以研究痛苦和精神痛苦，并确定偏头痛的潜在危险因素。方法对慢性偏头痛 (CM) 患者进行观察性横断面研究和发作性偏头痛 (EM) 和健康受试者 (HS)。三组的年龄和性别相匹配。对偏头痛残疾、疼痛、精神疾病、心身综合征、抑郁和焦虑症状、心境正常、社会心理变量、精神疼痛和疼痛倾向 (PP) 进行了全面评估。结果招募了 300 名受试者（100 CM、100 EM 和 100 HS）。根据多元回归分析，那些呈现 PP（社会障碍：优势比 [OR] = 3.59，95% 置信区间 [CI] = 1.14-11.29；抑郁症状：OR = 3.82，95% CI = 1.74-8.41）的人比 HS 更可能是 CM。PP 水平较高的人（社交障碍：OR = 4.04，95% CI = 1.60-10.22；抑郁症状：OR = 2.02，95% CI = 1.26-3.24）比 HS 更可能是 EM。与 EM 相比，那些表现出更高水平的精神痛苦的人更可能是 CM（OR = 1.45, 95% CI = 1.02-2.07）。个人。