AMPK is a crucial sensor of the cellular energetic state and is also activated during glucose starvation. A new study reports that AMP-activated protein kinase (AMPK) is activated by interaction with long-chain fatty acyl–CoA esters, which appear to be the long-sought endogenous AMPK ligands that bind the allosteric drug and metabolite (ADaM) site.

中文翻译：

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AMPK作为长链脂肪酰基辅酶A酯的直接传感器。

AMPK是细胞能量状态的关键传感器，在葡萄糖饥饿期间也会被激活。一项新的研究报告说，AMP活化的蛋白激酶（AMPK）通过与长链脂肪酰基-CoA酯的相互作用而被激活，长链脂肪酰基-CoA酯似乎是长期寻求的内源性AMPK配体，可结合变构药物和代谢物（ADaM）位点。