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Oncogenic splicing regulated by phase separation.
Nature Cell Biology ( IF 17.3 ) Pub Date : 2020-07-27 , DOI: 10.1038/s41556-020-0553-5
Bo Liu 1 , Omar Abdel-Wahab 1
Affiliation  

There is increasing appreciation that many proteins self-aggregate in cells to form functional subcompartments, some of which exist as a separate liquid phase. A study now identifies the biophysical properties of AKAP95 protein condensates as critical for supporting cancer cell proliferation and RNA splicing.

中文翻译:

致癌剪接受相分离调控。

人们越来越认识到,许多蛋白质会在细胞中自我聚集形成功能性的小室,其中一些以独立的液相形式存在。现在的一项研究确定了AKAP95蛋白缩合物的生物物理特性对支持癌细胞增殖和RNA剪接至关重要。
更新日期:2020-07-27
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