Self-Assembled Organic Nanomaterials for Drug Delivery, Bioimaging, and Cancer Therapy,ACS Biomaterials Science & Engineering

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Self-Assembled Organic Nanomaterials for Drug Delivery, Bioimaging, and Cancer Therapy
ACS Biomaterials Science & Engineering ( IF 5.4 ) Pub Date : 2020-07-26 , DOI: 10.1021/acsbiomaterials.0c00883
Yinfeng Zhang ₁ , Fang Fang ₂ , Li Li ₁ , Jinfeng Zhang ₂

Affiliation

Over the past few decades, tremendous progress has been made in the development of engineering nanomaterials, which opened new horizons in the field of diagnosis and treatment of various diseases. In particular, self-assembled organic nanomaterials with intriguing features including delicate structure tailoring, facile processability, low cost, and excellent biocompatibility have shown outstanding potential in biomedical applications because of the enhanced permeability and retention (EPR) effect and multifunctional properties. In this review, we briefly introduce distinctive merits of self-assembled organic nanomaterials for biomedical applications. The main focus will be placed on summarizing recent advances in self-assembled organic nanomedicine for drug delivery, bioimaging, and cancer phototherapy, followed by highlighting a critical perspective on further development of self-assembled organic nanomaterials for future clinical translation. We believe that the above themes will appeal to researchers from different fields, including material, chemical, and biological sciences, as well as pharmaceutics.

中文翻译：

自组装的有机纳米材料，用于药物输送，生物成像和癌症治疗

在过去的几十年中，工程纳米材料的开发取得了巨大进展，这为各种疾病的诊断和治疗领域开辟了新的视野。尤其是，具有增强的渗透性和保留（EPR）效果和多功能特性的自组装有机纳米材料具有令人着迷的功能，包括精细的结构剪裁，便捷的可加工性，低成本和出色的生物相容性，在生物医学应用中显示出了巨大的潜力。在这篇综述中，我们简要介绍了用于生物医学应用的自组装有机纳米材料的独特优点。主要重点将放在总结用于药物输送，生物成像和癌症光疗的自组装有机纳米药物的最新进展，接下来，重点介绍了对自组装有机纳米材料的进一步开发以进行未来临床翻译的批判性观点。我们相信上述主题将吸引来自不同领域的研究人员，包括材料，化学和生物科学以及药学。

更新日期：2020-09-14

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