ABSTRACT

PRNP genotypes, number of octarepeats (PHGGGWGQ) and indels in the PRNP promoter can influence the progression of prion disease in mammals. We found no relationship between presence of promoter indels in white-tailed deer and mule deer from Nebraska and CWD presence. White-tailed deer with the 95 H allele and G20D mule deer were more likely to be CWD-free, but unlike other studies white-tailed deer with the 96S allele(s) were equally likely to be CWD-free. We provide the first information on PRNP genotypes and indels in the promoter for Key deer (all homozygous 96SS) and Coues deer (lacked 95 H and 96S alleles, but possessed a uniquely high frequency of 103 T). All deer surveyed were homozygous for three tandem octarepeats.

摘要

PRNP 基因型、八重复序列 (PHGGGWGQ) 和 PRNP 启动子中的插入缺失会影响哺乳动物朊病毒疾病的进展。我们发现内布拉斯加州的白尾鹿和骡鹿中启动子插入缺失的存在与 CWD 的存在之间没有关系。具有 95 H 等位基因的白尾鹿和 G20D 骡鹿更有可能无 CWD，但与其他研究不同的是，具有 96S 等位基因的白尾鹿同样可能无 CWD。我们提供了有关 Key 鹿（均为纯合 96SS）和 Coues 鹿（缺乏 95 H 和 96S 等位基因，但具有 103 T 的独特高频）启动子中 PRNP 基因型和插入缺失的第一个信息。所有被调查的鹿都是纯合子的三个串联八重连。