Abstract

Cinnamic acids and their derivatives are found in abundance in fruits, vegetables, and other food products of plant origin. The trans-cinnamic and p-coumaric acids in particular have been a subject of research for the treatment of a diverse range of pathological conditions. However, it is unclear whether these derivatives exert a direct beneficial effect on the cells that play a role in regulating skin wound healing, such as fibroblasts. In this study, using in vitro scratch-wound healing assay, it was observed that treatment with trans-cinnamic acid resulted in increased migration of fibroblasts when compared with that of p-coumaric acid-treated cells, without any adverse effect on cell viability. Studies on the lipophilicity of these acids using the XLOGP3 algorithm showed that trans-cinnamic acid was more lipophilic than p-coumaric. Thus, the findings of this study indicated that the lipophilic characteristic of trans-cinnamic acid rendered it more suitable as a potential drug candidate.

摘要

肉桂酸及其衍生物大量存在于水果、蔬菜和其他植物源食品中。该反式-肉桂和p尤其香豆酸已经研究了各种不同的病理状态的治疗对象。然而，尚不清楚这些衍生物是否对在调节皮肤伤口愈合中发挥作用的细胞（如成纤维细胞）产生直接的有益影响。在这项研究中，使用体外划痕愈合试验，观察到反式肉桂酸处理导致成纤维细胞迁移增加，与p-香豆酸处理的细胞，对细胞活力没有任何不利影响。使用 XLOGP3 算法对这些酸的亲脂性进行的研究表明，反式肉桂酸比对香豆酸更具亲脂性。因此，该研究的结果表明反式肉桂酸的亲脂特性使其更适合作为潜在的候选药物。