ABSTRACT

Background

Type 2 diabetes mellitus (T2DM) is an international health concern. The C-X-C chemokine ligand 16 (CXCL16) functions as a scavenging cell surface receptor. Vitamin D3 has vital effects on inflammation and insulin homeostasis.

Purpose

To investigate the significance of serum CXCL 16 and vitamin D3 in T2DM patients to understand disease pathophysiology.

Materials and Methods

The current work was performed as a cross-sectional study.

The study included 60 participants, 30 patients with T2DM attending the national institute of diabetes clinics and 30 age and sex-matched healthy controls. Participants underwent the following: Serum CXCL16 by enzyme-linked immunosorbent assay (ELISA), vitaminD3 by radioimmuno assay(RIA), glycosylated hemoglobin (HbA1c), fasting blood sugar(FBS), thyroid stimulating hormone (TSH), liver and kidney functions.

Results and discussion

Serum CXCL16 levels were significantly higher and serum vitamin D3 levels were significantly lower in T2DM patients compared to controls (p < 0.00001). Serum CXCL16 levels correlated negatively with vitamin D3 levels (r = – 0.837 and p = 0.00001) while a negative correlation was recognized between vitaminD3 levels and HbA1c % in patients (r = −0.609 and p = 0.00035).

Conclusion

Serum CXCL16, vitamin D3 and HbA1 c may be important parameters in monitoring T2DM and predicting complications.

中文翻译：

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埃及2型糖尿病患者的循环CXCL16

摘要

背景

2型糖尿病（T2DM）是国际卫生关注的问题。CXC趋化因子配体16（CXCL16）充当清除细胞表面受体。维生素D3对炎症和胰岛素稳态具有至关重要的作用。

目的

调查血清CXCL 16和维生素D3在T2DM患者中的意义，以了解疾病的病理生理学。

材料和方法

当前的工作是作为横断面研究进行的。

该研究包括60名参与者，30名在美国糖尿病研究所就诊的2型糖尿病患者以及30名年龄和性别匹配的健康对照者。参与者进行了以下检查：通过酶联免疫吸附测定（ELISA）的血清CXCL16，通过放射免疫测定（RIA）的维生素D3，糖基化血红蛋白（HbA1c），空腹血糖（FBS），促甲状腺激素（TSH），肝和肾功能。

结果与讨论

与对照组相比，T2DM患者的血清CXCL16水平显着升高，血清维生素D3水平显着降低（p <0.00001）。血清CXCL16水平与维生素D3水平呈负相关（r = – 0.837和p = 0.00001），而患者的维生素D3水平与HbA1c％之间呈负相关（r = -0.609和p = 0.00035）。

结论

血清CXCL16，维生素D3和HbA1c可能是监测T2DM和预测并发症的重要参数。