MicroRNAs (miRNAs) refer to a class of small endogenous non-coding RNAs that regulate gene expression at the post-transcriptional level. Emerging studies have shown that miRNAs play critical roles in tumorigenesis and cancer progression. However, roles and mechanisms of miRNA dysregulation in the pathogenesis of meningioma are not fully understood. Here, we first reviewed existing research of aberrantly expressed miRNAs identified by high throughput microarray profiling in meningioma. We also explored the potential of miRNA as biomarkers and therapeutic targets for novel treatment paradigms of meningiomas. In addition, we summarized recent researches that focused on the possible mechanisms involved in miRNA-mediate meningioma occurrence and progression. This review provides an overview of miRNA deregulation in meningioma and indicates the potential of miRNAs to be used as biomarkers or novel therapeutic targets.

中文翻译：

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MicroRNAs 在脑膜瘤中的生物学和诊断作用。

MicroRNAs（miRNAs）是一类在转录后水平调控基因表达的小内源性非编码RNAs。新兴研究表明，miRNA 在肿瘤发生和癌症进展中起着关键作用。然而，miRNA 失调在脑膜瘤发病机制中的作用和机制尚不完全清楚。在这里，我们首先回顾了通过高通量微阵列分析在脑膜瘤中鉴定的异常表达的 miRNA 的现有研究。我们还探索了 miRNA 作为脑膜瘤新治疗范例的生物标志物和治疗靶点的潜力。此外，我们总结了最近的研究，重点关注 miRNA 介导的脑膜瘤发生和发展的可能机制。