Metal-organic frameworks (MOFs) have received much attention for their potential as chemical sensors, owing to unparalleled tunability of their host-guest response, high uptake and structural flexibility. However, because of the limited compatibility between MOF properties and sensor transduction mechanisms, very few MOFs have successfully been integrated into practical devices. We report the fabrication of the first strain-based sensor constructed from MOF nanoparticles deposited directly onto a membrane-type surface stress sensing architecture, which exhibits unprecedented response times on the order of seconds and ppm-level sensitivity towards volatile organic compounds (VOCs). Finite element analysis is used to demonstrate that the sensor response is a result of analyte-induced strain in the MOF receptor layer. We show that an array of four types of MOF nanoparticles allows for clear discrimination between different classes of VOCs and even individual gases, using principal component analysis of their response profiles. This work opens up the possibility of VOC sensing using a wide range of MOFs, beyond those that are electrically conducting or those that form oriented thin films, with the added advantages of high sensitivity and rapid response compared to existing MOF strain-based sensors.

金属有机框架（MOF）由于其作为客体传感器的无与伦比的可调节性，高吸收性和结构灵活性而备受关注，因为它们具有化学传感器的潜力。但是，由于MOF属性和传感器转换机制之间的兼容性有限，因此很少有MOF成功集成到实际设备中。我们报道了由MOF纳米颗粒直接沉积到膜型表面应力感测体系结构上构建的第一个基于应变的传感器的制造，该传感器表现出空前的响应时间，其秒数级和对挥发性有机化合物（VOC）的ppm级灵敏度。有限元分析用于证明传感器响应是MOF受体层中分析物引起的应变的结果。我们展示了使用四种类型的MOF纳米颗粒的阵列，可以通过对其响应曲线进行主成分分析，从而清楚地区分不同类别的VOC甚至单个气体。与现有的基于MOF应变的传感器相比，这项工作为使用导电性MOMO或形成定向薄膜的MOF提供了广泛的VOC传感可能性，并具有高灵敏度和快速响应的优势。