Acetaminophen (paracetamol) is used in dogs to manage fever and mild pain. The aim of this study was to assess the pharmacokinetics of acetaminophen in both fed and fasted Labrador Retrievers after a single intravenous and oral administration (20 mg/kg). Six healthy dogs underwent three treatments in a randomized block study (a, n = 2; b, n = 2; c, n = 2). In phase one, group a received acetaminophen intravenously, group b and c orally after being fasted and fed, respectively. In phase two and three, groups were swapped, and the experiment was repeated. At the end of the trial, each dog received the same treatment. Acetaminophen plasma concentrations were detected using a validated HPLC‐UV method. The pharmacokinetic analysis was performed using a noncompartmental model. Clearance, volume at steady state and half‐life of acetaminophen in Labrador Retrievers were 0.42 L/kg hr, 0.87 L/kg and 1.35 hr, respectively. No significant statistical differences were found between fasted and fed dogs regarding maximum plasma concentration, time at maximum concentration and bioavailability as measured by the AUC. Feeding does not significantly affect the acetaminophen oral pharmacokinetics.

中文翻译：

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禁食和喂养的拉布拉多犬静脉和口服给药后对乙酰氨基酚的药代动力学。

对乙酰氨基酚（扑热息痛）用于狗治疗发烧和轻微疼痛。本研究的目的是评估单次静脉内和口服给药 (20 mg/kg) 后，对喂食和禁食的拉布拉多犬对乙酰氨基酚的药代动力学。在一项随机区组研究中，六只健康狗接受了三种治疗（a，n = 2；b，n = 2；c，n = 2）。第一阶段，a组静脉注射对乙酰氨基酚，b组和c组分别禁食和进食后口服。在第二和第三阶段，交换小组，并重复实验。在试验结束时，每只狗都接受相同的治疗。使用经过验证的 HPLC-UV 方法检测对乙酰氨基酚的血浆浓度。使用非房室模型进行药代动力学分析。拉布拉多猎犬体内对乙酰氨基酚的清除率、稳态体积和半衰期分别为 0.42 L/kg hr、0.87 L/kg 和 1.35 hr。在最大血浆浓度、最大浓度时间和通过 AUC 测量的生物利用度方面，在禁食和喂食的狗之间没有发现显着的统计学差异。喂食对扑热息痛口服药代动力学没有显着影响。