Synthesis and biological evaluation of benzimidazole pendant cyanopyrimidine derivatives as anticancer agents,Journal of Heterocyclic Chemistry

当前位置： X-MOL 学术 › J. Heterocycl. Chem. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Synthesis and biological evaluation of benzimidazole pendant cyanopyrimidine derivatives as anticancer agents
Journal of Heterocyclic Chemistry ( IF 2.0 ) Pub Date : 2020-07-27 , DOI: 10.1002/jhet.4052
Wang Haoran ₁ , Wasim Akhtar ₂ , Lalit Mohan Nainwal ₁ , Sumit Kumar Kaushik ₁ , Mymoona Akhter ₁ , Mohammad Shaquiquzzaman ₁ , Mohammad Mumtaz Alam ₁

Affiliation

Thirteen new benzimidazole pendant cyanopyrimidine derivatives were synthesized. The compounds were synthesized through multistep reaction protocol. The structures of synthesized derivatives were studied by EI‐MS, ¹H NMR, FT‐IR and elemental analysis. All the compounds were studied for their anticancer activity at National Cancer Institute. Except compound 7j, all the compounds unveiled cytotoxicity against cancer cells. The most active compound 7a had shown highest value of growth inhibition of 88.44% and 84.19% against HOP‐92 and T‐47D cancer cell lines.

中文翻译：

苯并咪唑侧基氰基嘧啶衍生物的合成及生物学评价

合成了十三种新的苯并咪唑侧基氰基嘧啶衍生物。通过多步反应方案合成化合物。通过EI-MS，¹ H NMR，FT-IR和元素分析研究了合成衍生物的结构。美国国家癌症研究所研究了所有化合物的抗癌活性。除化合物7j外，所有化合物均具有针对癌细胞的细胞毒性。活性最高的化合物7a对HOP-92和T-47D癌细胞系的生长抑制作用最高，分别为88.44％和84.19％。

更新日期：2020-09-08

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11