Estrogen enhances browning in adipose tissue by M2 macrophage polarization via heme oxygenase-1.,Journal of Cellular Physiology

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Estrogen enhances browning in adipose tissue by M2 macrophage polarization via heme oxygenase-1.
Journal of Cellular Physiology ( IF 4.5 ) Pub Date : 2020-07-27 , DOI: 10.1002/jcp.29971
Ok-Joo Sul ₁ , Hyo-Jung Hyun ₁ , Monisha Rajasekaran ₁ , Jae-Hee Suh ₂ , Hye-Seon Choi ₁

Affiliation

Loss of ovarian function results in increased fat mass, leading to the accumulation of adipose tissue macrophages that participate in chronic inflammation. We hypothesized that ovariectomy (OVX)‐induced increases in body weight and fat mass are associated with decreased adipose tissue (AT) browning due to estrogen (E₂) deficiency. In mice, OVX decreased AT browning along with increased body weight, fat mass, and size of lipid droplets 12 weeks after surgery. Exogenous E₂ recovered the OVX‐induced changes. AT browning was enhanced by M2 macrophages induced by exogenous E_2. E₂‐induced M2 polarization occurred due to the increased expression of heme oxygenase‐1 (HO‐1) in macrophages, leading to decreased reactive oxygen species levels. Collectively, we demonstrated that E₂ enhances AT browning via M2 polarization mediated by HO‐1.

中文翻译：

雌激素通过血红素加氧酶 1 使 M2 巨噬细胞极化，从而增强脂肪组织的褐变。

卵巢功能丧失会导致脂肪量增加，导致参与慢性炎症的脂肪组织巨噬细胞积聚。我们假设卵巢切除术 (OVX) 引起的体重和脂肪量增加与雌激素 (E ₂ ) 缺乏导致的脂肪组织 (AT) 褐变减少有关。在小鼠中，手术后 12 周，OVX 减少了 AT 褐变，同时增加了体重、脂肪量和脂滴大小。外源E ₂恢复了OVX 诱导的变化。外源E ₂诱导的M2巨噬细胞增强了AT褐变。E ₂诱导的M2极化是由于巨噬细胞中血红素加氧酶-1 (HO-1)表达增加而发生，导致活性氧水平降低。总的来说，我们证明 E ₂通过 HO-1 介导的 M2 极化增强 AT 褐变。

更新日期：2020-07-27

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