Carboxylic acid responses by a conserved odorant receptor in culicine vector mosquitoes.,Insect Molecular Biology

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Carboxylic acid responses by a conserved odorant receptor in culicine vector mosquitoes.
Insect Molecular Biology ( IF 2.3 ) Pub Date : 2020-07-26 , DOI: 10.1111/imb.12661
Robert M Huff ₁ , R Jason Pitts ₁

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Many mosquito behaviours that are critical for survival and reproduction depend upon timely responses to chemical cues. Of interest are the effects of volatile organic compounds like carboxylic acids (CAs) that are released by potential blood meal hosts. Short chain CAs are among the primary attractants for host‐seeking females and influence host selection in vector species. Although the behavioural relevance of CA's has been established, less is known about the molecular receptive events that evoke responses to specific compounds, with the Ir family of chemoreceptors being broadly implicated in their detection. In this study, we demonstrate that Or orthologs from two vector species, Aedes aegypti (L.) and Aedes albopictus (Skuse), are selectively activated by straight chain carboxylic acids and that these responses are attenuated by the commercial insect repellant N,N‐Diethyl‐meta‐toluamide. Our results suggest that multiple chemoreceptors, representing diverse families, are able to mediate molecular responses to CAs and may therefore underlie important behaviours that directly impact disease‐transmission cycles.

中文翻译：

库里奇蚊子中保守的气味受体对羧酸的响应。

对于生存和繁殖至关重要的许多蚊子行为取决于对化学线索的及时响应。令人感兴趣的是潜在的血粉宿主释放的挥发性有机化合物（如羧酸（CA））的影响。短链CA是寻求寄主雌性的主要诱因之一，并影响媒介物种中寄主的选择。尽管已经建立了CA的行为相关性，但是对于引起对特定化合物的反应的分子接受事件知之甚少，Ir家族的化学感受器广泛地涉及其检测。在这项研究中，我们证明，或者由两个向量物种同源基因埃及伊蚊（L.）和白纹伊蚊（Skuse）被直链羧酸选择性激活，而这些反应被商业驱虫剂N，N-Diethyl-meta-toluamide减弱。我们的结果表明，代表不同家族的多个化学感受器能够介导对CA的分子反应，因此可能是直接影响疾病传播周期的重要行为的基础。

更新日期：2020-07-26

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