Carbon nanotubes (CN) have been studied to treat spinal cord injuries because of its electrical properties and nanometric dimensions. This work aims to develop a photopolymerizable hydrogel containing CN functionalized with an anti-inflammatory molecule to be used in situ on spinal cord injuries. The CN functionalization step was done using the drug (formononetin). The nanocomposites were characterized by morphological analysis, FTIR, Raman Spectroscopy, thermal analysis and cytotoxicity assays (MTT and HET-CAM). The nanocomposites were incorporated into gelatin methacryloyl hydrogel and exposed to UV light for photopolymerization. The volume of the formulation and the UV exposition time were also analyzed. The CN characterization showed that formononetin acted as a functionalization agent. The functionalized CN showed safe characteristics and can be incorporated in photocrosslinkable formulation. The UV exposition time for the formulation photopolymerization was compatible with the cell viability and also occurred in the injury site.

由于碳纳米管的电学性质和纳米尺寸，已经对其进行了研究以治疗脊髓损伤。这项工作旨在开发一种含有可被原位使用的抗炎分子官能化的CN的可光聚合水凝胶脊髓受伤。CN功能化步骤是使用该药物（甲酮）完成的。通过形态分析，FTIR，拉曼光谱，热分析和细胞毒性测定（MTT和HET-CAM）对纳米复合材料进行了表征。将纳米复合材料掺入明胶甲基丙烯酰基水凝胶中，并暴露于紫外光下进行光聚合。还分析了制剂的体积和UV暴露时间。CN的表征表明，formononetin起功能化剂的作用。官能化的CN显示安全特性，可以掺入可光交联的配方中。制剂光聚合的紫外线曝光时间与细胞活力兼容，并且也发生在损伤部位。