Ginseng has been used as reinforcing drugs or for traditional Chinese medicine in aging, inflammation, stress, diabetes mellitus, hepatic diseases and cancer. The aim of this current review is to provide an integrative overview of the uses, relative human diseases and related mechanisms of ginseng. Nowadays, numerous animal experiments and clinical studies conducted to investigate the efficacy and safety of ginseng components. Inflammation is an immune response that protects human from pathogens, toxins and other dangers, which is initiated by recognizing pathogen- or danger- associated molecular patterns. Inflammasomes are cytosolic protein complexes which form in response to challenges, which also controls the activity of caspase-1, important for maturation and release of cytokines. Ice protease-activating factor, oligomerization domain-like receptor family pyrin domain-containing 1 and absent in melanoma 2 inflammasome recognize peculiar substances, while NLRP3 inflammasome responds towards structurally and chemically diverse triggers. The functional relationship between ginsenosides and inflammasome provides new insight into the understanding of molecular mechanisms of ginsenoside-mediated anti-inflammatory actions. It also has applications regarding the development of anti-inflammatory remedies by ginsenoside-mediated targeting inflammasomes, which could prevent and treat inflammatory diseases.

人参已被用作抗衰老，炎症，压力，糖尿病，肝病和癌症的增强药物或中药。本次审查的目的是提供人参的用途，相对人类疾病和相关机制的综合概述。如今，进行了许多动物实验和临床研究，以研究人参成分的功效和安全性。炎症是一种免疫反应，可保护人类免受病原体，毒素和其他危险的侵害，这是通过识别与病原体或危险相关的分子模式而引发的。炎性体是响应挑战而形成的胞质蛋白复合物，它也控制caspase-1的活性，这对于细胞因子的成熟和释放很重要。冰蛋白酶激活因子 寡聚化结构域样受体家族的含吡喃结构域的1和黑色素瘤2的炎性小体中不存在识别特殊的物质，而NLRP3炎性小体对结构和化学上不同的触发信号作出反应。人参皂苷和炎症小体之间的功能关系为了解人参皂苷介导的抗炎作用的分子机制提供了新的见识。它也有关于人参皂苷介导的靶向炎症小体开发抗炎药物的应用，可以预防和治疗炎性疾病。人参皂苷和炎症小体之间的功能关系为了解人参皂苷介导的抗炎作用的分子机制提供了新的见识。它也有关于人参皂苷介导的靶向炎症小体开发抗炎药物的应用，可以预防和治疗炎性疾病。人参皂苷和炎症小体之间的功能关系为了解人参皂苷介导的抗炎作用的分子机制提供了新的见识。它也有关于人参皂苷介导的靶向炎症小体开发抗炎药物的应用，可以预防和治疗炎性疾病。