A novel type of catalytic static mixers with rectangular cross-section coated with Pd/Al₂O₃ has been developed. The catalytic mixers, produced by additive manufacturing and coated with the metal catalyst, have shown excellent catalytic performance for continuous flow hydrogenation of nitroaromatics. The heterogeneous catalyst is highly stable. No loss of catalytic performance was observed after long periods of activity and ICP-MS measurements determined that essentially no Pd or Al leaches from the reactor. The rectangular cross-section reactor is readily scalable. The process developed has been showcased for the synthesis of the key intermediate of the medicine tizanidine.

一种新型的具有矩形截面的催化静态混合器已被开发出来，并涂有 Pd/Al ₂ O ₃。通过增材制造生产并涂有金属催化剂的催化混合器对硝基芳烃的连续流动加氢显示出优异的催化性能。多相催化剂高度稳定。在长时间的活性之后没有观察到催化性能的损失，并且 ICP-MS 测量确定基本上没有 Pd 或 Al 从反应器中浸出。矩形截面反应器易于扩展。所开发的工艺已用于合成药物替扎尼定的关键中间体。