As one of the most serious threats to human being, cancer is hard to be treated when metastasis happens. What's worse, there are few identified targets of metastasis for drug development. Therefore, it is important to develop strategies to prevent metastasis or treat existed metastasis. This review focuses on the procedure of metastasis, and first summarizes the targeting delivery strategies, including primary tumor targeting drug delivery, tumor metastasis targeting drug delivery and hijacking circulation cells. Then, as a promising treatment, the application of immunotherapy in tumor metastasis treatment is introduced, and strategies that stimulating immune response are reviewed, including chemotherapy, photothermal therapy, photodynamic therapy, ferroptosis, sonodynamic therapy, and nanovaccines. Finally, the challenges and perspective about nanoparticle-enabled tumor metastasis treatment are discussed.

作为人类最严重的威胁之一，转移发生时很难治疗癌症。更糟糕的是，几乎没有确定的药物开发转移靶标。因此，制定预防转移或治疗已存在转移的策略非常重要。这篇综述着重于转移的过程，并且首先总结了靶向递送策略，包括原发性肿瘤靶向药物递送，肿瘤转移靶向药物递送和劫持循环细胞。然后，作为一种有前途的治疗方法，介绍了免疫疗法在肿瘤转移治疗中的应用，并综述了刺激免疫反应的策略，包括化学疗法，光热疗法，光动力疗法，肥大症，声动力疗法和纳米疫苗。最后，