Maternal obesity is an emerging problem in the modern world. Growing evidence suggests that intrauterine high-fat (HF) exposure may predispose progeny to subsequent metabolic challenges. Progeny born to mothers who ate an HF diet also tends to eat an HF diet when growing and aggravate metabolic issues. Thus, the generational transmission of obesity is cyclical. Developing a strategy to prevent the occurrence of metabolic syndrome related to prenatal and/or postnatal HF diet is important. In this study, the reprogramming effects of maternal resveratrol treatment for the progeny with maternal HF/postnatal HF diets were investigated. Sprague-Dawley dams were fed either a control or a high-fat/high sucrose diet (HFHS) from mating to lactation. After weaning, the progeny was fed chow or an HF diet. Four experimental groups were yielded: CC (maternal/postnatal control diet), HC (maternal HF/postnatal control diet), CH (maternal control/postnatal HFHS diet), and HH (maternal/postnatal HFHS diet). A fifth group (HRH) received a maternal HFHS diet plus maternal resveratrol treatment and a postnatal chow diet to study the effects of maternal resveratrol therapy. Maternal resveratrol treatment lessened the weight and adiposity of progeny that were programmed by combined prenatal and postnatal HFHS diets. Maternal resveratrol therapy ameliorated the decreased abundance of the sirtuin 1 (SIRT1) enzyme in retroperitoneal tissue and the altered leptin/soluble leptin receptor ratio of progeny. Maternal resveratrol therapy also decreased lipogenesis and increased lipolysis for progeny. Maternal resveratrol intervention can prevent adiposity programmed by maternal and postnatal HFHS diets by inducing lipid metabolic modulation. This study offers a novel reprogramming role for the effect of maternal resveratrol supplements against obesity.

中文翻译：

---

孕妇和哺乳期摄入白藜芦醇可重新设定肥胖的程序，并通过脂肪代谢调节，改善孕妇高脂/高蔗糖加上产后高脂/高蔗糖饮食对雄性后代的瘦素抵抗。

孕产妇肥胖是现代世界中一个新出现的问题。越来越多的证据表明，宫内高脂（HF）暴露可能使子代易于发生随后的代谢挑战。吃过高脂饮食的母亲所生的后代在成长时也倾向于食用高脂饮食，并加剧了新陈代谢的问题。因此，肥胖的世代传播是周期性的。制定预防与产前和/或产后HF饮食有关的代谢综合征的策略很重要。在这项研究中，研究了母体白藜芦醇对母体HF /产后HF饮食的后代的重编程作用。从交配到哺乳期，给Sprague-Dawley大坝喂饲对照或高脂/高蔗糖饮食（HFHS）。断奶后，给后代喂食物或HF饮食。产生了四个实验组：CC（母体/产后控制饮食），HC（母体HF /产后控制饮食），CH（母体/产后HFHS饮食）和HH（母体/产后HFHS饮食）。第五组（HRH）接受母体HFHS饮食加母体白藜芦醇治疗和产后松鼠饮食，以研究母体白藜芦醇治疗的效果。母体白藜芦醇治疗可减轻产前和产后HFHS饮食控制的体重和子代肥胖。母体白藜芦醇疗法改善了腹膜后组织中sirtuin 1（SIRT1）酶的丰度降低，并改善了子代瘦素/可溶性瘦素受体的比例。孕妇白藜芦醇治疗还可以减少脂肪生成，增加子代脂解作用。孕妇白藜芦醇的干预可以通过诱导脂质代谢调节来防止孕妇和产后HFHS饮食控制的肥胖。这项研究为孕妇白藜芦醇补充剂对抗肥胖提供了新颖的重编程作用。