Background. Esophageal cancer (EC), as a serious threat to human life and health, is one of the most common cancers around the world. Many studies have suggested that many microRNAs are involved in tumorigenesis and progression. Methods. To search for a novel and promising predictive therapeutic target or biomarker to achieve the goal of the early diagnosis and treatment of EC, we used the EC cell lines Eca-109 and KYSE-150 and normal human esophageal epithelial cells (HEECs) to investigate the effect of ABI3BP on EC. Results. We found that ABI family member 3 binding protein (ABI3BP) was downregulated in EC and suppressed the proliferation, activity, migration, and invasion of EC cells. ABI3BP was downregulated by miR-183, which plays the role of an oncogene. Conclusion. ABI3BP and miR-183 can be considered potential biomarkers for the diagnosis of patients with EC and can be effective targets for antitumor therapy.

中文翻译：

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MicroRNA-183 对 ABI3BP 的消耗促进了食管癌的发展。

背景。食管癌（EC）作为对人类生命和健康的严重威胁，是全球最常见的癌症之一。许多研究表明，许多 microRNA 参与了肿瘤的发生和进展。方法。为了寻找一种新的、有前景的预测治疗靶点或生物标志物以实现早期诊断和治疗 EC 的目标，我们使用 EC 细胞系 Eca-109 和 KYSE-150 以及正常人食管上皮细胞 (HEECs) 来研究ABI3BP 对 EC 的影响。结果。我们发现 ABI 家族成员 3 结合蛋白 (ABI3BP) 在 EC 中下调并抑制 EC 细胞的增殖、活性、迁移和侵袭。ABI3BP 被 miR-183 下调，miR-183 发挥癌基因的作用。结论。ABI3BP 和 miR-183 可以被认为是诊断 EC 患者的潜在生物标志物，并且可以成为抗肿瘤治疗的有效靶点。