Background The progression of Parkinsons disease (PD) can often exacerbate symptoms of depression, anxiety, and/or cognitive impairment. In this study, we explore the possibility that multiple brain network responses are associated with symptoms of depression, anxiety and cognitive impairment in PD. This association is likely to provide insights into a single multivariate relationship, where common affective symptoms occurring in PD cohorts are related with alterations to electrophysiological response. Methods 70 PD patients and 21 healthy age-matched controls (HC) participated in a high-density electroencephalography (EEG) study. Functional connectivity differences between PD and HC groups of oscillatory activity at rest and during completion of an emotion-cognition task were examined to identify key brain oscillatory activities. A canonical correlation analysis (CCA) was applied to identify a putative multivariate relationship between connectivity patterns and affective symptoms in PD groups. Results A CCA analysis identified a single mode of co-variation linking theta and gamma connectivity with affective symptoms in PD groups. Increases in frontotemporal gamma, frontal and parietal theta connectivity were related with increased anxiety and cognitive impairment. Decreases in temporal region theta and frontoparietal gamma connectivity were associated with higher depression ratings and PD patient age. Limitations This study only reports on optimal dosage of dopaminergic treatment (on state) in PD and did not investigate at off medication. Conclusions Theta and gamma connectivity during rest and task-states are linked to affective and cognitive symptoms within fronto-temporo-parietal networks, suggesting a potential assessment avenue for understanding brain-behavior associations in PD with electrophysiological task paradigms.

中文翻译：

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θ和γ活性与帕金森氏病的情感和认知症状有关

背景帕金森病（PD）的进展通常会加剧抑郁症，焦虑症和/或认知障碍的症状。在这项研究中，我们探讨了多种脑网络反应与PD的抑郁，焦虑和认知障碍症状相关的可能性。这种关联可能会提供对单个多元关系的见解，其中PD队列中发生的常见情感症状与电生理反应的改变有关。方法70例PD患者和21例健康的年龄匹配对照（HC）参加了高密度脑电图（EEG）研究。检查了在休息和完成情绪认知任务过程中PD和HC振荡活动的功能连通性差异，以识别关键的大脑振荡活动。应用规范相关分析（CCA）来确定PD组的连通性模式与情感症状之间的推定多变量关系。结果CCA分析确定了PD组中将theta和γ连通性与情感症状联系在一起的协方差的单一模式。额颞γ，额叶和顶叶theta连通性的增加与焦虑和认知障碍的增加有关。颞区theta和额前额叶γ连通性的降低与抑郁评分较高和PD患者年龄有关。局限性这项研究仅报告了PD中多巴胺能治疗的最佳剂量（处于状态），未进行非药物治疗的研究。