During adolescence, neuronal circuits exhibit plasticity in response to physiological changes and to adapt to environmental events. Nigrostriatal dopaminergic pathways are in constant flux during development. Evidence suggests a relationship between early use of cannabinoids and psychiatric disorders characterized by altered dopaminergic systems, such as schizophrenia and addiction. However, it remains unclear what is the impact of adolescent exposure to cannabinoids on nigrostriatal dopaminergic pathways in adulthood. The aim of this research is to determine the effects of repeated activation of cannabinoid receptors during adolescence on dopaminergic activity of nigrostriatal pathways and the mechanisms underlying this impact during the adulthood.

中文翻译：

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青少年暴露于 WIN 55212-2 会使黑质纹状体多巴胺能通路在成年期被激活。

在青春期，神经元回路表现出响应生理变化和适应环境事件的可塑性。黑质纹状体多巴胺能通路在发育过程中不断变化。有证据表明，早期使用大麻素与以多巴胺能系统改变为特征的精神疾病（例如精神分裂症和成瘾）之间存在关系。然而，目前尚不清楚青少年接触大麻素对成年黑质纹状体多巴胺能通路的影响。本研究的目的是确定青春期大麻素受体重复激活对黑质纹状体通路多巴胺能活性的影响，以及成年期这种影响的潜在机制。