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β-Glucan ameliorates nonalcoholic steatohepatitis induced by methionine and choline-deficient diet in mice.
Journal of Food Biochemistry ( IF 3.5 ) Pub Date : 2020-07-26 , DOI: 10.1111/jfbc.13408
Tianyang Huang 1 , Yahui Liu 2 , Huiming Li 1 , Ying Zhang 1 , Dezhi Kong 3 , Guozhen Cui 1
Affiliation  

Nonalcoholic steatohepatitis (NASH) is becoming a huge global health problem. Studies showed that β‐glucan displayed potent anti‐inflammatory and other multi‐beneficial pharmacological properties. Thus, the objective of this study was to investigate the effects of β‐glucan on NASH mice induced by the MCD diet. After 8 weeks of β‐glucan treatments, results showed that β‐glucan effectively decreased the serum ALT and AST levels compared with the MCD model. Besides, histopathological results demonstrated that β‐glucan significantly attenuated the fat accumulation, steatosis, and inflammation in the liver compared with that of the MCD group. Furthermore, the ER stress‐responsive proteins, including GRP78, p‐eiF‐2α, and p‐JNK, were markedly restrained by β‐glucan, while ERp57, p‐MAPK, and p‐Akt were significantly increased after β‐glucan treatment. Collectively, our results suggested that β‐glucan beneficially resisted NASH induced by the MCD diet. The ER stress response may be involved in the mechanisms of action of β‐glucan.

中文翻译:


β-葡聚糖可改善由蛋氨酸和胆碱缺乏饮食引起的小鼠非酒精性脂肪性肝炎。



非酒精性脂肪性肝炎(NASH)正在成为一个巨大的全球健康问题。研究表明,β-葡聚糖具有有效的抗炎作用和其他多种有益的药理特性。因此,本研究的目的是研究 β-葡聚糖对 MCD 饮食诱导的 NASH 小鼠的影响。经过8周的β-葡聚糖治疗,结果显示,与MCD模型相比,β-葡聚糖有效降低了血清ALT和AST水平。此外,组织病理学结果表明,与 MCD 组相比,β-葡聚糖显着减轻肝脏中的脂肪积累、脂肪变性和炎症。此外,β-葡聚糖显着抑制了内质网应激反应蛋白,包括 GRP78、p-eiF-2α 和 p-JNK,而 ERp57、p-MAPK 和 p-Akt 在 β-葡聚糖处理后显着增加。 。总的来说,我们的结果表明 β-葡聚糖有益于抵抗 MCD 饮食引起的 NASH。内质网应激反应可能参与β-葡聚糖的作用机制。
更新日期:2020-07-26
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