Multifunctional nanocomposites that possess imaging and high-performance therapeutic features are experiencing a surge in interest in the precision clinical anticancer treatment. In this work, we reported the fabrication and bio-application of a novel persistent luminescence-polypyrrole nanocomposite (LPLNP@SPP) for photoacoustic/persistent luminescence (PA/PL) dual-modal imaging guided photothermal therapy (PTT). The construction of LPLNP@SPP avoids the PL quenching of LPLNP-OH by the polypyrrole-coating, and thus enables the combination of PL and PTT. The LPLNP@SPP shows excellent biocompatibility, long lasting near-infrared (NIR) PL emitting without in situ excitation and high-contrast PA signals. Meanwhile, this nanocomposite exhibits strong NIR absorbance and exceptional photothermal conversion capability, which provides notable potential for imaging-guided antitumor therapy. Thus, our work highlights the dual-functional core-shell LPLNP@SPP as a feasible theranostic nanoplatform for cancer diagnosis and therapy.

具有成像和高性能治疗功能的多功能纳米复合材料正受到人们对精确临床抗癌治疗的关注。在这项工作中，我们报道了一种新型的持久发光-聚吡咯纳米复合材料（LPLNP @ SPP）的制备和生物应用，用于光声/持久发光（PA / PL）双模式成像引导光热疗法（PTT）。LPLNP @ SPP的构建避免了通过聚吡咯涂层对LPLNP-OH的PL淬灭，从而实现了PL和PTT的结合。LPLNP @ SPP具有出色的生物相容性，可发出持久的近红外（NIR）PL，而无需原位激发和高对比度PA信号。同时，这种纳米复合材料具有很强的近红外吸收率和出色的光热转换能力，这为影像引导的抗肿瘤治疗提供了显着的潜力。因此，我们的工作强调了双功能核壳LPLNP @ SPP是用于癌症诊断和治疗的可行治疗方法纳米平台。