Producing high-competent oocytes during the in vitro maturation (IVM) is considered a key step for the success of the in vitro production (IVP) of embryos. One of the known disruptors of oocyte developmental competence on IVP is oxidative stress (OS), which appears due to the imbalance between the production and neutralization of reactive oxygen species (ROS). The in vitro conditions induce supraphysiological ROS levels due to the exposure to an oxidative environment and the isolation of the oocyte from the follicle protective antioxidant milieu. In juvenile in vitro embryo transfer (JIVET), which aims to produce embryos from prepubertal females, the oocytes are more sensitive to OS as they have inherent lower quality. Therefore, the IVM strategies that aim to prevent OS have great interest for both IVP and JIVET programs. The focus of this review is on the effects of ROS on oocyte IVM and the main antioxidants that have been tested for protecting the oocyte from OS. Considering the importance that OS has on oocyte competence, it is crucial to create standardized antioxidant IVM systems for improving the overall IVP success.

在体外成熟（IVM）过程中产生高能力的卵母细胞被认为是胚胎体外生产（IVP）成功的关键步骤。氧化应激（OS）是已知的卵母细胞对IVP发育能力的破坏因素之一，氧化应激是由于活性氧（ROS）的产生和中和之间的不平衡而出现的。在体外条件下诱导超生理ROS水平由于暴露到氧化环境，并从毛囊抗氧化保护环境的卵母细胞的分离。在青少年中胚胎移植（JIVET）旨在从青春期前的雌性中产生胚胎，卵母细胞由于其固有的较低质量而对OS更敏感。因此，旨在防止操作系统的IVM策略对IVP和JIVET程序都非常感兴趣。这篇综述的重点是ROS对卵母细胞IVM的作用以及已被测试用于保护卵母细胞免受OS侵害的主要抗氧化剂。考虑到OS对卵母细胞功能的重要性，创建标准化的抗氧化剂IVM系统对于提高IVP的整体成功至关重要。