Anti- RI antibody associated progressive supranuclear palsy like presentation in a patient with breast carcinoma,Journal of Neuroimmunology

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Anti- RI antibody associated progressive supranuclear palsy like presentation in a patient with breast carcinoma
Journal of Neuroimmunology ( IF 2.9 ) Pub Date : 2020-10-01 , DOI: 10.1016/j.jneuroim.2020.577345
Aastha Takkar ₁ , Sahil Mehta ₁ , Nalini Gupta ₂ , Saurabh Bansal ₁ , Vivek Lal ₁

Affiliation

Paraneoplastic neurological syndromes (PNS) are well established entities associated with onconeural antibodies. Paraneoplastic parkinsonism is a highly under narrated presentation of PNS. Rapid progression of typical or atypical parkinsonism with red flags like multiaxial involvement, complete gaze palsy and a clinico-radiological mismatch should prompt a clinician to suspect secondary etiologies like infection, metabolic, vascular, metastatic and paraneoplastic causes. We describe a patient with rapidly progressive parkinsonism. Diagnosis of Breast carcinoma associated ANNA-2/ Anti Ri mediated PSP like phenotype was made in this patient based upon clinical examination and investigations. We also present a review of literature on paraneoplastic parkinsonism in this manuscript.

中文翻译：

抗 RI 抗体与乳腺癌患者的进行性核上性麻痹样表现有关

副肿瘤神经综合征 (PNS) 是与肿瘤神经抗体相关的公认实体。副肿瘤性帕金森综合征是 PNS 的一种被高度低估的表现。典型或非典型帕金森病的快速进展伴有多轴受累、完全性凝视麻痹和临床放射学不匹配等危险信号，应促使临床医生怀疑继发性病因，如感染、代谢、血管、转移和副肿瘤原因。我们描述了一名患有快速进展性帕金森病的患者。根据临床检查和调查，在该患者中诊断出乳腺癌相关的 ANNA-2/抗 Ri 介导的 PSP 样表型。我们还在这份手稿中回顾了关于副肿瘤性帕金森病的文献。

更新日期：2020-10-01

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