Two novel triphenyltin(IV) compounds, [Ph₃SnL1] (L1 = 2-(5-(4-fluorobenzylidene)-2,4-dioxotetrahydrothiazole-3-yl)propanoate (1)) and [Ph₃SnL2] (L2 = 2-(5-(5-methyl-2-furfurylidene)-2,4-dioxotetrahydrothiazole-3-yl)propanoate (2)) were synthesized and characterized by FT-IR, (¹H and ¹³C) NMR spectroscopy, mass spectrometry, and elemental microanalysis. The in vitro anticancer activity of the synthesized organotin(IV) compounds was determined against four tumor cell lines: PC-3 (prostate), HT-29 (colon), MCF-7 (breast), and HepG2 (hepatic) using MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-12 diphenyltetrazolium bromide) and CV (crystal violet) assays. The IC₅₀ values are found to be in the range from 0.11 to 0.50 μM. Compound 1 exhibits the highest activity toward PC-3 cells (IC₅₀ = 0.115 ± 0.009 μM; CV assay). The tin and platinum uptake in PC-3 cells showed a threefold lower uptake of tin in comparison to platinum (as cisplatin). Together with its higher activity this indicates a much higher cell inhibition potential of the tin compounds (calculated to ca. 50 to 100 times). Morphological analysis suggested that the compounds induce apoptosis in PC-3 cells, and flow cytometry analysis revealed that 1 and 2 induce autophagy as well as NO (nitric oxide) production.

两种新型三苯基锡（IV）化合物[ Ph ₃ SnL1]（L1  = 2-（5-（4-氟亚苄基）-2,4-二氧四氢噻唑-3-基）丙酸酯（1））和[ Ph ₃ SnL2]（L2 ＝ 合成2-（5-（5-（5-甲基-2-糠基亚基）-2，4-二氧四氢噻唑-3-基）丙酸酯（2）），并通过FT-IR，（¹ H和¹³ C）NMR光谱表征，质谱和元素微量分析。在体外使用MTT测定了合成的有机锡（IV）化合物对四种肿瘤细胞系的抗癌活性：PC-3（前列腺），HT-29（结肠），MCF-7（乳腺癌）和HepG2（肝） 4,5-二甲基噻唑-2-基）-2,5-12溴化二苯基四唑）和CV（结晶紫）分析。发现IC ₅₀值在0.11至0.50μM的范围内。化合物1对PC-3细胞表现出最高活性（IC ₅₀  = 0.115±0.009μM； CV分析）。与铂（顺铂）相比，PC-3细胞中锡和铂的吸收显示锡吸收降低了三倍。连同其较高的活性，这表明锡化合物具有更高的细胞抑制潜能（计算为约50至100次）。形态分析表明该化合物诱导PC-3细胞凋亡，流式细胞仪分析表明1和2诱导自噬以及NO（一氧化氮）产生。