Abstract

The melanocortin-4 receptor (MC4r) located in the hypothalamus is an important element of the signaling pathway involved in the regulation of animal energy homeostasis. There are numerous cases of variability of the MC4r gene that cause the appearance of desirable features from the point of view of breeding progress. In this study, the sequences of the MC4r gene were determined, a series of SNP variations were found in both the coding and non-coding regions of the gene.Two equipotent herds of chinchillas, breeding in accordance with open or closed nucleus program, were examined for the presence of identified variations. It was found that between analyzed herds occurs statistically significant differences in the frequency of genotypes and in the abundance of genetic pools. A potentially significant in terms of breeding process polymorphism c.-136G>A in 5'UTR MC4r gene was observed in both herds.

中文翻译：

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繁殖体系对龙猫（Melchinorina）Melanocortin-4受体（MC4r）基因核苷酸变异的影响。

摘要

位于下丘脑的黑皮质素4受体（MC4r）是参与调节动物能量稳态的信号通路的重要元素。从育种进展的角度来看，存在许多MC4r基因变异的情况，这些变异导致所需特征的出现。在这项研究中，MC4r的序列确定了该基因，在该基因的编码区和非编码区均发现了一系列SNP变异。检查了根据开放或闭合核程序繁殖的两只等能力的龙猫群是否存在已鉴定的变异。发现在分析的畜群之间，基因型的频率和遗传库的数量在统计学上存在显着差异。在两个牛群中均观察到在5'UTR MC4r基因的繁殖过程多态性c.-136G> A方面具有潜在的意义。