Abstract

The analysis of the relative expression of the Ca²⁺-ATPase SERCA2a gene (ATP2A2) and the ryanodine receptor (RYR2) gene in the myocardium of 85 patients with coronary artery disease complicated by heart failure, depending on the clinical picture of the disease, was performed. A decrease in the expression level of the ATP2A2 and RYR2 genes in patients with left ventricular hypertrophy was revealed. It was established that the expression level of the RYR2 gene decreased with the severity of the functional class of heart failure. A correlation was found between the expression level of the ATP2A2 gene and the echocardiography parameters.

中文翻译：

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慢性心力衰竭患者Ca 2+ -ATPase SERCA2a（ATP2A2）基因和Ryanodine受体（RYR2）基因的表达。

摘要

根据该疾病的临床情况，分析85例冠心病并发心力衰竭患者心肌中Ca ²⁺ -ATPase SERCA2a基因（ATP2A2）和ryanodine受体（RYR2）基因的相对表达，被执行了。发现左心室肥厚患者的ATP2A2和RYR2基因表达水平降低。已经确定，RYR2基因的表达水平随着心力衰竭功能类别的严重性而降低。发现ATP2A2基因的表达水平与超声心动图参数之间存在相关性。