Isavuconazole is a triazole antifungal available in IV and capsule formulation. Prescribing information states that capsules should not be chewed, crushed, dissolved or opened because the drug was not studied in this manner. However, considering the pharmacokinetics of the capsules, we theorized opening and sprinkling the contents into an enteral feeding tube (EFT) would result in adequate absorption and systemic concentrations of isavuconazole.

中文翻译：

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通过肠饲管施用硫酸依沙康那唑硫酸盐胶囊可达到移植受者中临床依沙康康唑的血药浓度。

Isavuconazole是三唑类抗真菌药，可通过IV和胶囊制剂获得。处方信息指出，不应咀嚼，压碎，溶解或打开胶囊，因为没有以这种方式研究药物。但是，考虑到胶囊的药代动力学，我们理论上将内含物打开并将其撒入肠内饲管（EFT）中会导致充分吸收和全身吸收艾沙康康唑。