Epigenetic changes may result from the interplay of environmental exposures and genetic influences and contribute to differences in age‐related disease, disability, and mortality risk. However, the etiologies contributing to stability and change in DNA methylation have rarely been examined longitudinally.

中文翻译：

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衰老双胞胎的十年表观遗传变化：纵向 DNA 甲基化的遗传和环境贡献。

表观遗传变化可能源于环境暴露和遗传影响的相互作用，并导致与年龄相关的疾病、残疾和死亡风险的差异。然而，很少有人对导致 DNA 甲基化稳定性和变化的病因进行纵向研究。