Isobavachalcone ameliorates diabetic nephropathy in rats by inhibiting the NF-κB pathway.,Journal of Food Biochemistry

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Isobavachalcone ameliorates diabetic nephropathy in rats by inhibiting the NF-κB pathway.
Journal of Food Biochemistry ( IF 3.5 ) Pub Date : 2020-07-25 , DOI: 10.1111/jfbc.13405
Wen-Hong Dong ₁ , Qiang-Qiang Chu ₁ , Shang-Quan Liu ₂ , Da-Tong Deng ₃ , Qian Xu ₃

Affiliation

Isobavachalcone (ISO) exhibits good anti‐inflammatory activity. We evaluated the renoprotective effects of ISO against diabetic nephropathy (DN). Diabetic rats established by the single injection of streptozotocin (STZ) were orally treated with ISO. The levels of serum creatinine (Scr), blood urea nitrogen (BUN), and 24 hr urinary protein were measured. In this study, ISO effectively ameliorated renal damage by reducing BUN, Scr, and 24 hr urinary protein and also improved kidney pathological appearances. ISO prevented STZ‐caused apoptosis in the glomerular tissue in vivo and blocked the high glucose (HG)‐induced growth inhibitory effect in human renal glomerular endothelial cells in vitro. Moreover, ISO reduced pro‐inflammatory mediator production and blocked the NF‐κB pathway in the damaged renal tissues and HG‐treated HRGEC cells. Taken together, the results of this study indicate that ISO consumption might have significant beneficial effects on the DN and this action might be correlated with the modulation of the NF‐κB pathway.

中文翻译：

异巴伐康酮通过抑制NF-κB途径改善大鼠糖尿病肾病。

异巴伐康酮（ISO）具有良好的抗炎活性。我们评估了ISO对糖尿病肾病（DN）的肾脏保护作用。单次注射链脲佐菌素（STZ）建立的糖尿病大鼠用ISO口服治疗。测量血清肌酐（Scr），血尿素氮（BUN）和24小时尿蛋白的水平。在这项研究中，ISO通过减少BUN，Scr和24小时尿蛋白有效地改善了肾脏损害，并改善了肾脏的病理表现。ISO可以在体内阻止STZ引起的肾小球组织凋亡，并在体外阻断高葡萄糖（HG）诱导的人肾小球内皮细胞生长抑制作用。此外，ISO减少了受损肾脏组织和经HG处理的HRGEC细胞中促炎性介质的产生，并阻断了NF-κB途径。

更新日期：2020-09-14

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