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Environmental enrichment restores impaired spatial memory and synaptic plasticity in prenatally stress exposed rats: the role of GABAergic neurotransmission
International Journal of Developmental Neuroscience ( IF 1.7 ) Pub Date : 2020-08-07 , DOI: 10.1002/jdn.10052
Fatemeh Aghighi Bidgoli 1 , Mahmoud Salami 1 , Sayyed Alireza Talaei 1
Affiliation  

Evidence shows that prenatal stress negatively affects cognitive functions and activity of neuronal circuits in postnatal age. Environmental enrichment counteracts deficits induced by early life stress. We examined if behavioural function and synaptic plasticity are sensitive to prenatal stress and, how much environmental enrichment and GABAergic system impact these phenomena. Animals were exposed to noise stress during the third trimester of foetal life. Groups of the stressed animals remained intact (S‐SH) or received enrichment (S‐EE) from postnatal day 22 for one month. Also, two groups received either saline (S‐SH‐S) or bicuculline (S‐SH‐B). One enriched group received muscimol (S‐EE‐M). The control groups were intact (C‐SH), enriched (C‐EE), or received bicuculline (C‐SH‐B) or saline (C‐SH‐S). We assessed learning and memory and, hippocampal long‐term potentiation (LTP). Serum corticosterone levels were detected as a measure of stress condition. We found that stress reduced spatial performance and suppressed LTP in the S‐SH animals. Postnatal enrichment restored both spatial learning and memory and synaptic plasticity in the S‐EE rats. GABAergic antagonism strengthens maze performance and LTP induction in the S‐SH‐B group. However, muscimol prevented the positive effects of enrichment in the S‐EE‐M animals. Environmental enrichment and GABAergic modulation may improve disrupted spatial performance and synaptic plasticity.

中文翻译:

环境富集恢复产前应激暴露大鼠受损的空间记忆和突触可塑性:GABA能神经传递的作用

有证据表明,产前压力会对出生后的认知功能和神经元回路的活动产生负面影响。丰富的环境可以抵消早期生活压力引起的缺陷。我们检查了行为功能和突触可塑性是否对产前压力敏感,以及环境富集和 GABA 能系统对这些现象的影响程度。动物在胎儿生命的第三个三个月期间暴露于噪音压力中。从出生后第 22 天开始,一组应激动物保持完整 (S-SH) 或接受浓缩 (S-EE) 一个月。此外,两组接受盐水 (S-SH-S) 或荷包牡丹碱 (S-SH-B)。一个富集组接受 muscimol (S-EE-M)。对照组是完整的 (C-SH)、富集的 (C-EE) 或接受荷包牡丹碱 (C-SH-B) 或盐水 (C-SH-S)。我们评估了学习和记忆,并且,海马长时程增强(LTP)。检测血清皮质酮水平作为压力状况的量度。我们发现压力会降低 S-SH 动物的空间表现并抑制 LTP。产后富集恢复了 S-EE 大鼠的空间学习和记忆以及突触可塑性。GABA 能拮抗作用增强了 S-SH-B 组的迷宫性能和 LTP 诱导。然而,muscimol 阻止了 S-EE-M 动物富集的积极影响。环境富集和 GABA 能调节可能会改善被破坏的空间性能和突触可塑性。产后富集恢复了 S-EE 大鼠的空间学习和记忆以及突触可塑性。GABA 能拮抗作用增强了 S-SH-B 组的迷宫性能和 LTP 诱导。然而,muscimol 阻止了 S-EE-M 动物富集的积极影响。环境富集和 GABA 能调节可能会改善被破坏的空间性能和突触可塑性。产后富集恢复了 S-EE 大鼠的空间学习和记忆以及突触可塑性。GABA 能拮抗作用增强了 S-SH-B 组的迷宫性能和 LTP 诱导。然而,muscimol 阻止了 S-EE-M 动物富集的积极影响。环境富集和 GABA 能调节可能会改善被破坏的空间性能和突触可塑性。
更新日期:2020-08-07
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