Serum level of soluble urokinase plasminogen activator receptor (suPAR) as a disease severity marker of myasthenia gravis: a pilot study.,Clinical & Experimental Immunology

当前位置： X-MOL 学术 › Clin. Exp. Immunol. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Serum level of soluble urokinase plasminogen activator receptor (suPAR) as a disease severity marker of myasthenia gravis: a pilot study.
Clinical & Experimental Immunology ( IF 3.4 ) Pub Date : 2020-07-24 , DOI: 10.1111/cei.13499
A Uzawa ₁ , Y Kojima _{1,

2} , Y Ozawa ₁ , M Yasuda ₁ , Y Onishi ₁ , H Akamine ₁ , N Kawaguchi _{1,

3} , K Himuro _{1,

4} , S Kuwabara ₁

Affiliation

Myasthenia gravis (MG) is an autoantibody‐mediated inflammatory disease of the neuromuscular junction. Biomarkers indicating disease activity in MG are warranted. Recently, the soluble urokinase plasminogen activator receptor (suPAR) has been reported to be associated with inflammation, tissue damage, disease activity and prognosis in various diseases, including autoimmune diseases. In this study, serum suPAR levels were measured in 40 patients with anti‐acetylcholine receptor antibody‐positive MG and 30 controls, and their correlations with clinical variables and severity scale scores were investigated. We identified that serum suPAR levels significantly correlated with MG activities of daily living scale (Spearman’s ρ = 0·45; P = 0·004) and MG Foundation of America classification (Spearman’s ρ = 0·37; P = 0·02) at serum sampling, but not with anti‐acetylcholine receptor antibody titers. In conclusion, serum suPAR levels can be a candidate for a novel biomarker of disease activity in anti‐acetylcholine receptor antibody‐positive MG.

中文翻译：

作为重症肌无力疾病严重程度标志物的可溶性尿激酶纤溶酶原激活剂受体 (suPAR) 的血清水平：一项初步研究。

重症肌无力（MG）是一种自身抗体介导的神经肌肉接头炎症性疾病。指示 MG 疾病活动的生物标志物是有必要的。最近，据报道可溶性尿激酶纤溶酶原激活物受体 (suPAR) 与多种疾病（包括自身免疫性疾病）的炎症、组织损伤、疾病活动和预后有关。在这项研究中，测量了 40 名抗乙酰胆碱受体抗体阳性 MG 患者和 30 名对照组的血清 suPAR 水平，并研究了它们与临床变量和严重程度量表评分的相关性。我们发现血清suPAR水平与MG日常生活活动量表（Spearman's ρ = 0·45；P = 0·004）和美国MG基金会分类（Spearman's ρ = 0·37；P = 0·02）在血清采样时，但不是抗乙酰胆碱受体抗体滴度。总之，血清 suPAR 水平可以作为抗乙酰胆碱受体抗体阳性 MG 疾病活动的新型生物标志物的候选者。

更新日期：2020-07-24

点击分享查看原文

点击收藏

阅读更多本刊最新论文