The development of high-performance glucose sensors is an urgent need, especially for diabetes mellitus diagnosis. However, the glucose monitoring is conventionally operated in an invasive finger-prick manner and their noninvasive alternatives largely suffered from the relatively poor sensitivity, selectivity, and stability, resulted from the lack of robust and efficient catalysts. In this paper, we design a concave shaped nitrogen-doped carbon framework embellished with single Co site catalyst (Co SSC) by selectively controlling the etching rate on different facet of carbon substrate, which is beneficial to the diffusion and contact of analyte. The Co SSC prompts a significant improvement in the sensitivity of the solution-gated graphene transistor (SGGT) devices, with three orders of magnitude better than those of SGGT devices without catalysts. Our findings expand the field of single site catalyst in the application of biosensors, diabetes diagnostics and personalized health-care monitoring.

开发高性能的葡萄糖传感器是当务之急，尤其是对于糖尿病的诊断。然而，葡萄糖监测通常以侵入性的手指采血方式进行，它们的非侵入性替代方案在很大程度上受到灵敏度、选择性和稳定性相对较差的影响，这是由于缺乏稳健和高效的催化剂造成的。在本文中，我们通过选择性地控制碳基板不同面上的蚀刻速率，设计了一种凹形的氮掺杂碳框架，其修饰有单 Co 位点催化剂（Co SSC），这有利于分析物的扩散和接触。Co SSC 促使溶液门控石墨烯晶体管 (SGGT) 器件的灵敏度显着提高，比没有催化剂的 SGGT 器件高三个数量级。