A series of Pt(II) complexes of the type [Pt(1,10-phenanthroline)(SArF_n)₂] (SArF_n = SC₆H₃-3,4-F₂ (1); SC₆F₄-4-H (2); SC₆F₅ (3)) were synthesized from [Pt(1,10-phenanthroline)(Cl)₂] and [Pb(SArF_n)₂] via metathesis reactions. The complexes were fully characterized including the unambiguous determination of their molecular structures by single-crystal X-ray diffraction techniques, showing the metal centers to be into a slightly distorted square-planar environments. The in vitro cytotoxic activity of the complexes was evaluated on six cancerous cell lines, i.e: glial cells of nervous central system (U-251), prostate (PC-3), leukemia (K-562), colon (HCT-15), breast (MCF-7) and lung (SKLU-1); we also included a healthy cell line of COS-7 (African green monkey kidney) for comparative purposes. We found that complex 2 was selective for PC-3. In addition, the IC₅₀ values for the series of complexes were determined using the U-251, HCT-15 and SKLU-1 cancerous cell lines, as well as in the healthy cell line (COS-7), where complex 1 exhibited the best activity, with IC₅₀ values going from 4.56 to 4.78 μM. These studies where further complemented with DNA docking theoretical calculations and DNA affinity experiments.

一系列的Pt（II）的类型[PT（1,10-菲咯啉）（SARF的络合物的_Ñ）₂ ]（SARF _Ñ  = SC ₆ H ^ ₃ -3,4-F ₂ （1） ; SC ₆ ˚F ₄ -通过[Pt（1,10-菲咯啉）（Cl）₂ ]和[Pb（SArF _n）₂ ]合成4-H （2） ; SC ₆ F ₅ （3））。复分解反应。对该络合物进行了充分表征，包括通过单晶X射线衍射技术明确确定了它们的分子结构，表明金属中心处于略微扭曲的方平面环境中。在体外的复合物的细胞毒活性在六个癌细胞系，进行了评价，即：神经中央系统的神经胶质细胞（U-251），前列腺癌（PC-3），白血病（K-562），结肠（HCT-15） ，乳房（MCF-7）和肺（SKLU-1）；为了进行比较，我们还包括一个健康的COS-7细胞系（非洲绿猴肾）。我们发现复合物2对PC-3具有选择性。另外，IC ₅₀使用U-251，HCT-15和SKLU-1癌细胞系以及健康细胞系（COS-7）（其中配合物1表现出最佳活性）使用IC ₅₀确定系列配合物的值值从4.56降至4.78μM。这些研究进一步辅以DNA对接理论计算和DNA亲和力实验。