Abstract Herein, an interfacial mass transfer process based on hollow fiber membrane assisted antisolvent crystallization (MAAC) was studied via real-time microscopic and computational fluid dynamic (CFD) method. The micro-scale antisolvent liquid layer was clearly detected on the antisolvent/solution interface. The antisolvent concentration and layer thickness were determined by different refractive index of the mixing fluid. CFD simulation results also confirmed the formation of uniform supersaturation gradient, indicating the approximate two-dimensional liquid layer mass transfer on the membrane surface. The competition effect between the feed solution shear force and antisolvent permeation flow rendered the high adjustability of the liquid layer features. Experimental comparison between MAAC and conventional AC indicated that crystal production obtained by MAAC possessed narrower size distribution and great morphology without defects. This novel interfacial liquid layer mass transfer mechanism opens a new approach for novel antisolvent crystallization with intensified interfacial mass transfer.

中文翻译：

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膜辅助反溶剂结晶中界面液层传质的可视化研究和模拟

摘要 在此，通过实时显微和计算流体动力学（CFD）方法研究了基于中空纤维膜辅助抗溶剂结晶（MAAC）的界面传质过程。在反溶剂/溶液界面上可以清楚地检测到微尺度反溶剂液层。反溶剂浓度和层厚由混合流体的不同折射率决定。CFD 模拟结果也证实了均匀过饱和梯度的形成，表明膜表面近似二维液层传质。进料溶液剪切力和反溶剂渗透流之间的竞争效应使得液层特征具有高度的可调节性。MAAC 与常规活性炭的实验比较表明，MAAC 获得的晶体产品具有更窄的尺寸分布和良好的无缺陷形态。这种新型的界面液层传质机制为具有强化界面传质的新型抗溶剂结晶开辟了一条新途径。