Abstract

Gastric cancer (GC) is still ranked fourth among malignant cancers and remained as the second leading cause of cancer related death. There is mounting evidence that emphasizes on the need for further investigation on the specific receptors overexpression roles in GC progression. Low efficiency and impotence of the common methods for targeting gastric tumorigenesis and related metastases are enough to convince researchers to continue their investigation on new approaches of effective GC targeting. Due to the suitable characteristics of peptides, such as high affinity and specificity, they have great potential for cancer cell targeting. Overexpression of specific targets in GC can facilitate the application of peptide-based pharmaceuticals for effective tumor targeting and therapy and early diagnosis with help of fluorescents or radionuclides. In this review article, we paid particular attention to the characterization of peptide-based pharmaceuticals and radiopharmaceuticals that have been investigated in recent years for GC diagnosis and therapy.

Graphic Abstract

中文翻译：

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肽在胃癌中的关键作用：诊断和治疗

摘要

胃癌（GC）在恶性癌症中仍然排名第四，并且仍然是与癌症相关的死亡的第二大主要原因。越来越多的证据强调需要进一步研究在GC进展中特定受体过表达的作用。靶向胃肿瘤发生和相关转移的常见方法效率低下且阳imp，足以说服研究人员继续研究有效靶向GC的新方法。由于肽的合适特性，例如高亲和力和特异性，它们具有靶向癌细胞的巨大潜力。GC中特定靶标的过表达可以促进基于肽的药物在有效靶向肿瘤和治疗以及借助荧光或放射性核素的早期诊断中的应用。

图形摘要