We constructed a multifunctional (Fe3O4/nGO)@mSiO2/GQDs drug carrier for loading and microwave-controlled release of an etoposide (VP16) as the anticancer drug. This nanocomposite consisted of magnetic core Fe3O4, microwave-absorbing nanographene oxide (nGO), fluorescent graphene quantum dots (GQDs) and intermediate barrier layer (mesoporous silica). It has a large surface area of 359.8[Formula: see text]m2/g, excellent fluorescence emission and ample magnetic performance of 36.00[Formula: see text]emu/g. After microwave irradiation for 140 s, the temperature of (Fe3O4/nGO)@mSiO2/GQDs nanoparticles rapidly went up to 90∘C. The loading rate of VP16 was as high as 68%, the release rate reached 87% within 280[Formula: see text]min under microwave irradiation. Therefore, the functionalized (Fe3O4/nGO)@mSiO2/GQDs nanoparticles will have potential application for clinical treatment as drug delivery system.

中文翻译：

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一种抗癌药物的微波控制释放策略：(Fe3O4/nGO)@mSiO2/GQDs 纳米复合载体由nGO和GQDs联合增强

我们构建了一个多功能（Fe3○4/nGO)@mSiO2/GQDs 药物载体，用于装载和微波控制释放作为抗癌药物的依托泊苷 (VP16)。这种纳米复合材料由磁芯 Fe 组成3○4、微波吸收纳米氧化石墨烯（nGO）、荧光石墨烯量子点（GQDs）和中间阻挡层（介孔二氧化硅）。它具有359.8的大表面积[公式：见正文]m2/g，出色的荧光发射和充足的磁性能36.00[公式：见正文]emu/g。微波照射 140 s 后，(Fe3○4/nGO)@mSiO2/GQDs 纳米粒子迅速上升到 90∘C.微波照射下VP16的负载率高达68%，释放率在280[公式：见正文]min内达到87%。因此，功能化（Fe3○4/nGO)@mSiO2/GQDs纳米粒子将作为药物输送系统在临床治疗中具有潜在应用。